NIH-12848


CAS No. : 959551-10-1

959551-10-1
Price and Availability of CAS No. : 959551-10-1
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Cat. No. : HY-101423
M.Wt: 385.41
Formula: C20H14F3N3S
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL (259.46 mM)
Introduction of 959551-10-1 :

NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM. IC50 & Target: IC50: 1 μM (PI5P4Kγ)[1] In Vitro: NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes’ on the culture dish. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks[1].

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