NIH-12848
CAS No. : 959551-10-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $51 | In-stock |
| 5mg | $108 | In-stock |
| 10mg | $150 | In-stock |
| 50mg | $540 | In-stock |
| 100mg | $900 | In-stock |
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| Cat. No. : | HY-101423 |
| M.Wt: | 385.41 |
| Formula: | C20H14F3N3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL (259.46 mM) |
NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM. IC50 & Target: IC50: 1 μM (PI5P4Kγ)[1] In Vitro: NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes’ on the culture dish. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks[1].
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