CAS No. : 959551-10-1

Price and Availability of CAS No. : 959551-10-1
Size Price Stock
5mg $108 In-stock
10mg $150 In-stock
50mg $540 In-stock
100mg $900 In-stock
200 mg Get quote
500 mg Get quote
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-101423
M.Wt: 385.41
Formula: C20H14F3N3S
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL (259.46 mM)
Introduction of 959551-10-1 :

NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM. IC50 & Target: IC50: 1 μM (PI5P4Kγ)[1] In Vitro: NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes’ on the culture dish. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks[1].

Your information is safe with us.