PTP1B-IN-4
CAS No. : 765317-72-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $109 | In-stock |
| 5mg | $230 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $800 | In-stock |
| 50mg | $1280 | In-stock |
| 100mg | $2100 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15756 |
| M.Wt: | 741.45 |
| Formula: | C26H19Br2N3O7S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes[1][2]. IC50 & Target:IC50: 8 μM (PTP1B)[1] In Vitro: PTP1B-IN-4 (250 μM; 1 hour) stimulates insulin receptor (IR) phosphorylation in CHO cells overexpressing human IR[1].
PTP1B-IN-4 also induces phosphorylation of IRS-1 and Akt, proteins downstream of the insulin receptor[1].
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