Cucurbitacin B
CAS No. : 6199-67-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $57 | In-stock |
| 5mg | $120 | In-stock |
| 10mg | $204 | In-stock |
| 25mg | $408 | In-stock |
| 50mg | $720 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-N0416 |
| M.Wt: | 558.70 |
| Formula: | C32H46O8 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : 1 mg/mL (ultrasonic) |
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity[1][2][3][4][5].
In Vitro:Cucurbitacin B (up to 40 μM, 12-48 h) inhibits the cell growth and arrests cell cycle progression at the G2/M phase in CCA cell lines [2].
Cucurbitacin B (0.1, 0.3 and 1 μM) increases the level of total superoxide dismutase(T-SOD) and SOD-1, but decrease the reactive oxygen species (ROS) and malondialdehyde (MDA) in BY4741 yeast cells[3].
In Vivo:Cucurbitacin B (5 mg/kg, oral administration 10day) B shows protective effects against carrageenan-induced prostatitis in rats[4].
Cucurbitacin B (20-50 mg/kg for i.p., 28 day) B afford a decline in AD symptoms and protects neurons against STZ-ICV toxicity that improved memory functions in rats[5].
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