Size | Price | Stock |
---|---|---|
5mg | $60 | In-stock |
10mg | $106 | In-stock |
50mg | $380 | In-stock |
100mg | $650 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-N0133 |
M.Wt: | 372.37 |
Formula: | C20H20O7 |
Purity: | >98 % |
Solubility: | DMSO : 25 mg/mL (67.14 mM; Need ultrasonic) |
Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and is a Notch-1 inhibitor. IC50 & Target: Notch-1 In Vitro: Tangeretin enhanced the radiosensitivity of GC cells as demonstrated by MTT and colony formation assays. Tangeretin also attenuated radiation-induced EMT, invasion and migration in GC cells, accompanied by a decrease in Notch-1, Jagged1/2, Hey-1 and Hes-1 expressions. Tangeretin triggered the upregulation of miR-410, a tumor-suppressive microRNA. Furthermore, re-expression of miR-410 prevented radiation-induced EMT and cell invasion [1]. In Vivo: In this study, we investigated the in vivo anti-RSV activity of tangeretin in 3-week-old male BALB/c mice. A plaque reduction assay and fluorescence quantitative polymerase chain reaction (FQ-PCR) showed that tangeretin inhibited RSV replication in the lung of mice [2].
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