Daucosterol
CAS No. : 474-58-8
(Synonyms: Eleutheroside A; β-Sitosterol β-D-glucoside)
| Size | Price | Stock |
|---|---|---|
| 5mg | $84 | In-stock |
| 10mg | $132 | In-stock |
| 25mg | $264 | In-stock |
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| Cat. No. : | HY-N0410 |
| M.Wt: | 576.85 |
| Formula: | C35H60O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 3.33 mg/mL (ultrasonic) |
Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway[1][2][3].
In Vitro:Daucosterol (0.01-100 μM, 48 h) inhibits the proliferation of MCF-7, AGS, MGC803 and BGC823 cells in a dose-dependent manner, with IC50s of 19.96 μM, 3.13 μM, 24.19 μM and 16.95 μM, respectively[1].
Daucosterol (50 μM, 24 h) significantly increases ROS production in MCF-7 and BGC823 cells[1].
Daucosterol (0-80 μM, 48 h) inhibits proliferation and promotes apoptosis in PC3 and LNCap cells[2].
In Vivo:Daucosterol (0.5-2.5 mg/kg, p.o., once per day for 7 days) significantly inhibits the H22 tumor growth in ICR mice inoculated with H22 hepatoma cells[1].
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