HT-2157


CAS No. : 303149-14-6

(Synonyms: SNAP 37889)

303149-14-6
Price and Availability of CAS No. : 303149-14-6
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1mg $108 In-stock
5mg $324 In-stock
10mg $516 In-stock
50mg $1560 In-stock
100mg $2520 In-stock
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Cat. No. : HY-100717
M.Wt: 366.34
Formula: C21H13F3N2O
Purity: >98 %
Solubility: DMSO : ≥ 29 mg/mL (79.16 mM)
Introduction of 303149-14-6 :

HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3). IC50 & Target: Galanin-3 receptor[1] In Vitro: HT-2157 (SNAP 37889) binds with high affinity to membranes from transiently transfected LMTK- cells expressing the human Gal3 receptor (Ki=17.44±0.01 nM; n>100) and is highly selective for Gal3 over the Gal1 and Gal2 subtypes (Ki>10,000 nM for each subtype; n=46 of each subtype). When tested for the antagonism of galanin-evoked inhibition of adenylyl cyclase, HT-2157 (0.1-10 μM) produces concentration-dependent rightward shifts of the concentration-effect curve to galanin[1]. In Vivo: The galanin-3 receptor antagonist, HT-2157 (SNAP 37889), reduces operant responding for ethanol in alcohol-preferring rats. The novel selective GALR3 antagonist, HT-2157, to reduce anxiety-like behaviour and voluntary ethanol consumption in the iP (alcohol-preferring) rat. Male iP rats treated with HT-2157 at a dose of 30 mg/kg (i.p.) do not show altered locomotor activity or changes in anxiety-like behaviour in the elevated plus maze or light-dark paradigms. Treatment with HT-2157 (30 mg/kg, i.p.) reduces operant responding for solutions containing ethanol, sucrose and saccharin. Collectively, results from the current study shows that HT-2157 (30 mg/kg, i.p.) is effective in reducing operant responding for ethanol, independent of a sedative effect[2].

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