Ralometostat
CAS No. : 2760481-53-4
(Synonyms: TNG908)
| Size | Price | Stock |
|---|---|---|
| 5mg | $190 | In-stock |
| 10mg | $304 | In-stock |
| 25mg | $495 | In-stock |
| 50mg | $690 | In-stock |
| 100mg | $970 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-148419 |
| M.Wt: | 409.50 |
| Formula: | C21H23N5O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
TNG908 is a MTAP synergistic PRMT5 inhibitor. TNG908 crosses the blood-brain barrier and is orally active. TNG908 could be used in cancer research[1].
In Vitro: TNG908 (0-10 μM, 24 h) is 15 times more selective for MTAPnull cell lines than MTAPWT cell lines, and the stability of human liver microsomes is C< sub>lint=14 μL/min/mg[1].
In Vivo: TNG908 (1-120 mg/kg twice daily for 21 days, p.o. or i.v.) A promotes tumor regression in LU99 NSCLC cell line-derived xenograft mouse model[1].
Pharmacokinetic Analysis in SD Rats[1]
| Route | Dose (mg/kg) | clearance (mL/min/kg) | Vss_obs (L/kg) | T1/2 (h) | Cmax (μg/mL) | AUCINF (μg·h/mL) |
| p.o. | 1 | 38.2 | 1.5 | 2 | / | / |
| p.o. | 3 | / | / | / | 0.6 | 2.5 |