BI-4142
CAS No. : 2682003-36-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $720 | In-stock |
| 100mg | $1080 | In-stock |
| 250mg | $2162 | In-stock |
| 500mg | $3243 | In-stock |
| 1g | $4865 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-150024 |
| M.Wt: | 521.57 |
| Formula: | C28H27N9O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
BI-4142 is a potent, highly selective and orally active HER2 inhibitor with an IC50 of 5 nM[1].
In Vitro: BI-4142 shows inhibition with IC50 values of 10 nM, 18 nM, 270 nM and 2400 nM against HEK HER2YVMA, Ba/F3 HER2YVMA, HEK EGFRWT and Ba/F3 EGFRWT, respectively[1].
BI-4142 (1 nM-5 μM, 72?h or 96?h) shows antiproliferative activity against tumor cells[1].
BI-4142 displays good permeability and no PgP-mediated efflux liability in the CaCo-2 assay[1].
BI-4142 inhibits HER2-dependent cell lines and inhibits downstream signaling[1].
In Vivo: BI-4142 (0-100 mg/kg; p.o.; twice per day for 40 days) inhibits tumor growth and inhibits oncogenic signaling[1].
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