GNE-7883
CAS No. : 2648450-42-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $144 | In-stock |
| 5mg | $360 | In-stock |
| 10mg | $580 | In-stock |
| 50mg | $1250 | In-stock |
| 100mg | $1750 | In-stock |
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| Cat. No. : | HY-147214 |
| M.Wt: | 500.57 |
| Formula: | C28H29FN6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
GNE-7883 is a pan-TEAD inhibitor that blocks the association of YAP/TAZ with TEAD. GNE-7883 effectively reduces chromatin accessibility at TEAD motifs, inhibits cell proliferation in multiple cell line models, and achieves strong anti-tumor efficacy in vivo. In addition, GNE-7883 effectively overcomes intrinsic and acquired resistance to KRAS (Kirsten rat sarcoma viral oncogene homolog) G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation[1][2][3]. IC50 & Target:TEAD[1]. In Vitro:GNE-7883 exhibits strong dose-dependent antiproliferative effects in both OVCAR-8 and NCI-H226 cells, with EC50 values of 115 nM and 333 nM, respectively[3]. In Vivo:GNE-7883 (100 and 250 mg/kg; s.c.; once daily for 4 days) induces tumor growth arrest in NCI-H226 xenograft mice and tumor regression in MSTO-211H xenograft mice[1].
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