TH1760
CAS No. : 2567914-01-4
| Size | Price | Stock |
|---|---|---|
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| 10mg | $90 | Get quote |
| 25mg | $210 | Get quote |
| 50mg | $395 | Get quote |
| 100 mg | Get quote | |
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| Cat. No. : | HY-139193 |
| M.Wt: | 426.45 |
| Formula: | C20H18N4O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TH1760 is an inhibitor of NUDIX-type 15 (NUDT15) with an IC50 value of 25 nM. TH1760 sensitizes cells to 6-thioguanine by enhancing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 enhances the anti-leukemia effect of thiopurine[1][2].
IC50 & Target:NUDIX-type 15, NUDT15[1]
In Vitro:TH1760 (0-100 µM) maintains the thermal denaturation of NUDT15 with dose-dependent manner[1].
TH1760 (0, 5, 10, 20 and 50 µM) increases the accumulation of thiopurine (6-TG) with dose-dependent manner in NB4 and HL-60 cells[1].
TH1760 (10 µM) increases the sensitivity of HCT116 and HCT116 3-6 cells to 6-TG. TH1760. TH1760 is more sensitive to BJ-RAS cells than BJ-hTERT cells[1].
TH1760 (10 µM; 16 h) promotes the accumulation and incorporation of 6-TG in HL-60 cells. TH1760 increases the expression of γH2AX, caspase3, Cleaved and cPARP in HL-60 cells[1].
TH1760 (0.05, 0.17, 0.55 and 1.8 µM; 4 d) enhances the anti-leukemia effect of 6-TG in a dose dependent manner[2].
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