m-PEG16-azide
CAS No. : 2564606-73-9
| Size | Price | Stock |
|---|---|---|
| 100mg | $655 | In-stock |
| 250mg | $1105 | In-stock |
| 1g | $1770 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-140831 |
| M.Wt: | 761.90 |
| Formula: | C33H67N3O16 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
m-PEG16-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG16-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
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