DBCO-PEG8-NHS ester
CAS No. : 2553412-88-5
| Size | Price | Stock |
|---|---|---|
| 25mg | $215 | In-stock |
| 50mg | $345 | In-stock |
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| Cat. No. : | HY-140273 |
| M.Wt: | 825.90 |
| Formula: | C42H55N3O14 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
DBCO-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG8-NHS ester is a click chemistry reagent, itcontains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
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