MRT68921 (dihydrochloride)

CAS No. : 2080306-21-2

Price and Availability of CAS No. : 2080306-21-2
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5mg $72 In-stock
10mg $120 In-stock
25mg $240 In-stock
50mg $432 In-stock
100mg $564 In-stock
200mg $1020 In-stock
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Cat. No. : HY-100006A
M.Wt: 471.04
Formula: C25H35ClN6O
Purity: >98 %
Storage: at 20℃ 2 years
Solubility: H2O : 10 mg/mL (21.23 mM; Need ultrasonic and warming)
Introduction of 2080306-21-2 :

MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively[1]. In Vitro: ULK1, a serine/threonine protein kinase, is essential for the initial stages of autophagy. MRT68921 inhibits ULK1 and ULK2 in vitro and block autophagy in cells. MRT68921 is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nm) and greater than a 30-fold reduction for ULK2 (1.1 nm). Autophagy-inhibiting capacity of the compounds is specifically through ULK1. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation[1].

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