Size | Price | Stock |
---|---|---|
5mg | $25 | In-stock |
10mg | $40 | In-stock |
25mg | $80 | In-stock |
50mg | $130 | In-stock |
100mg | $200 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-100508 |
M.Wt: | 292.12 |
Formula: | C13H7Cl2N3O |
Purity: | >98 % |
Solubility: | DMSO : ≥ 32 mg/mL (109.54 mM) |
ITSA-1 is an activator of histone deacetylase (HDAC), and counteract trichostatin A (TSA)-induced cell cycle arrest, histone acetylation, and transcriptional activation[1].
IC50 & Target: HDAC[1]
In Vitro: ITSA1 (50 μM; A549 cells) treatment serves to revert the TSA-arrested population to a normal cell cycle distribution. ITSA1 is also able to effect cell cycle rescue over longer duration[1].
ITSA1 (50 μM; 5 hours; A549 cells) treatment reduces the number of apoptosis in TSA-treated cells[1].
ITSA1 (50 μM; 2 hours; A549 and murine ES cells cells) treatment suppresses TSA-induced histone acetylation. Importantly, suppression of acetylation levels is only observable when ITSA1 is added concurrent with or post TSA treatment[1].
ITSA1 (50 μM; 30 minutes; murine ES cells cells) suppresses TSA-activated transcription in murine ES cells[1].
In Vivo: ITSA-1 (0.5 mg/kg; intraperitoneal injection; 3 times/week; for 8 weeks; CBS+/− mice) treatment balances deacetylation activity and suppresses IL-6 and TNF-α expression and thereby attenuated histone acetylationdependent infammatory signaling[2].
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