KDM5A-IN-1


CAS No. : 1905481-36-8

1905481-36-8
Price and Availability of CAS No. : 1905481-36-8
Size Price Stock
1mg $180 In-stock
5mg $420 In-stock
10mg $600 In-stock
50mg $1800 In-stock
100mg $2520 In-stock
200 mg Get quote
500 mg Get quote
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-100014
M.Wt: 290.36
Formula: C15H22N4O2
Purity: >98 %
Storage: at 20℃ 2 years
Solubility: DMSO : ≥ 50 mg/mL (172.20 mM)
Introduction of 1905481-36-8 :

KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B)[1]. IC50 & Target: IC50: 45 nM (KDM5A), 56 nM (KDM5B) and 55 nM (KDM5C)[1] In Vivo: KDM5A-IN-1 (Compound 50, 5 mg/kg; oral administration; female CD-1 mice) treatment shows moderate clearance (28 mL/min/kg) in mice with good oral bioavailability (F% 34) and remarkably low plasma protein binding in mice (40%), with t1/2 of 0.4 hours[1].

Your information is safe with us.