BAY-876


CAS No. : 1799753-84-6

1799753-84-6
Price and Availability of CAS No. : 1799753-84-6
Size Price Stock
100 mg Get quote
250 mg Get quote
500 mg Get quote
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-100017
M.Wt: 496.42
Formula: C24H16F4N6O2
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL (201.44 mM); H2O : < 0.1 mg/mL (insoluble)
Introduction of 1799753-84-6 :

BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4[1]. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth[2]. IC50 & Target: IC50: 2 nM (GLUT1)[1] In Vitro: BAY-876 (25-75 nM; 24 and 72 hours) has the growth-inhibitory effect and leads to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells[2]. In Vivo: BAY-876 (oral administration; 1.5-4.5 mg/kg/day for 28 days) causes a clear dose-dependent inhibition of tumorigenicity in mice[2].

Your information is safe with us.