BAY-876
CAS No. : 1799753-84-6
| Size | Price | Stock |
|---|---|---|
| 2mg | $96 | In-stock |
| 5mg | $120 | In-stock |
| 10mg | $180 | In-stock |
| 50mg | $540 | In-stock |
| 100mg | $900 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100017 |
| M.Wt: | 496.42 |
| Formula: | C24H16F4N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL (201.44 mM); Methanol : 1 mg/mL (2.01 mM; ultrasonic and warming and heat to 60°C) |
BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4[1]. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth[2]. IC50 & Target: IC50: 2 nM (GLUT1)[1] In Vitro: BAY-876 (25-75 nM; 24 and 72 hours) has the growth-inhibitory effect and leads to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells[2]. In Vivo: BAY-876 (oral administration; 1.5-4.5 mg/kg/day for 28 days) causes a clear dose-dependent inhibition of tumorigenicity in mice[2].
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