BAY-876
CAS No. : 1799753-84-6
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| Cat. No. : | HY-100017 |
| M.Wt: | 496.42 |
| Formula: | C24H16F4N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL (201.44 mM); H2O : < 0.1 mg/mL (insoluble) |
BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4[1]. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth[2]. IC50 & Target: IC50: 2 nM (GLUT1)[1] In Vitro: BAY-876 (25-75 nM; 24 and 72 hours) has the growth-inhibitory effect and leads to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells[2]. In Vivo: BAY-876 (oral administration; 1.5-4.5 mg/kg/day for 28 days) causes a clear dose-dependent inhibition of tumorigenicity in mice[2].
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- BAY-876
- Cat. No.:
- HY-100017
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