CAS No. : 179068-02-1

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Cat. No. : HY-100409
M.Wt: 294.30
Formula: C17H14N2O3
Purity: >98 %
Solubility: DMSO : 12.5 mg/mL (42.47 mM; Need ultrasonic)
Introduction of 179068-02-1 :

PHCCC is a Group I mGluR antagonist with an IC50 of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect[1][2]. In Vitro: PHCCC potentiated the effect of L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) in inhibiting transmission at the striatopallidal synapse[2]. In Vivo: PHCCC (75 nmol/2.5 μl; intracerebroventricular) produces an antiparkinsonian effect in a dopamine depletion akinesia model[2].

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