Namodenoson
CAS No. : 163042-96-4
(Synonyms: CF-102; 2-Cl-IB-MECA)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $720 | In-stock |
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| Cat. No. : | HY-12365 |
| M.Wt: | 544.73 |
| Formula: | C18H18ClIN6O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 31 mg/mL (56.91 mM) |
Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (Ki=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively[1][2]. IC50 & Target:Ki:0.33 nM (A3 adenosine receptor)[1][2]. In Vitro: In human ADF cells of astroglial lineage, 100 nM Namodenoson (2-Cl-IB-MECA) caused a marked reorganization of the cytoskeleton, with appearance of stress fibres and numerous cell protrusions. High concentrations of Namodenoson (2-Cl-IB-MECA) directly cause influx of Ca2+[2]. In Vivo: Intravenous administration of 200 μg/kg Namodenoson (2-Cl-IB-MECA) resulted in a short-lasting hypotension, which was accompanied by a 50-100-fold increase in plasma histamine concentrations. Administration of a second dose of Namodenoson (2-Cl-IB-MECA) did not elicit any hemodynamic effects[1].
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