CAS No. : 163042-96-4

(Synonyms: CF-102; 2-Cl-IB-MECA)

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Cat. No. : HY-12365
M.Wt: 544.73
Formula: C18H18ClIN6O4
Purity: >98 %
Solubility: DMSO : ≥ 31 mg/mL (56.91 mM)
Introduction of 163042-96-4 :

Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (Ki=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively[1][2]. IC50 & Target: Ki:0.33 nM (A3 adenosine receptor)[1][2]. In Vitro: In human ADF cells of astroglial lineage, 100 nM Namodenoson (2-Cl-IB-MECA) caused a marked reorganization of the cytoskeleton, with appearance of stress fibres and numerous cell protrusions. High concentrations of Namodenoson (2-Cl-IB-MECA) directly cause influx of Ca2+[2]. In Vivo: Intravenous administration of 200 μg/kg Namodenoson (2-Cl-IB-MECA) resulted in a short-lasting hypotension, which was accompanied by a 50-100-fold increase in plasma histamine concentrations. Administration of a second dose of Namodenoson (2-Cl-IB-MECA) did not elicit any hemodynamic effects[1].

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