Orismilast
CAS No. : 1353546-86-7
(Synonyms: LEO-32731)
| Size | Price | Stock |
|---|---|---|
| 5mg | $500 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1650 | In-stock |
| 50mg | $2600 | In-stock |
| 100mg | $4200 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117960 |
| M.Wt: | 510.29 |
| Formula: | C19H15Cl2F2NO7S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Orismilast (LEO-32731) is an orally active and selective PDE4 inhibitor used for the research of inflammatory diseases. Orismilast demonstrates potent inhibition of PDE4B and PDE4D subtype splice variants[1][2]. In Vitro:Orismilast inhibits tumour necrosis factor α (TNFα), and the secretion of T-helper (Th)1 (TNFα and IFNγ), Th17 (IL-22 and IL-23), and Th2 (IL-4, IL-5, and IL-13) related cytokines in PBMC[2]. In Vivo:Orismilast (10 and 30mg/kg) significantly reduces ear thickness and inflammation markers (p<0.0001, respectively)[2].
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