Galiellalactone
CAS No. : 133613-71-5
| Size | Price | Stock |
|---|---|---|
| 500μg | $514 | Get quote |
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| Cat. No. : | HY-125170 |
| M.Wt: | 194.23 |
| Formula: | C11H14O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer[1][2][3].
IC50 & Target: IC50: 250-500 nM (STAT3)[3]
In Vitro: Galiellalactone (2.5-25 μM; 24-72 hour) induces apoptosis of prostate cancer (PCa) cell lines expressingp-Stat3[1].
Galiellalactone (2.5-25 μM; 24-72 hour) decreases viability of DU145 cells[1].
Galiellalactone (10 μM) inhibits STAT3 signaling activity as assessed by luciferase reporter gene assay in IL-6-stimulated LNCaP cells[2].
Galiellalactone (10-100 μM; 1 hour) binds directly to STAT3 in DU145 cells [2].
Galiellalactone (5-50 μM; 1 hour) interferes with STAT3 DNA binding without inhibiting phosphorylation in DU145 cells [2].
In Vivo: Galiellalactone (1, 3 mg/kg; daily i.p. for 3 weeks) inhibits PCa tumor growth in vivo[1].
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