Q203


CAS No. : 1334719-95-7

(Synonyms: IAP6; Telacebec)

1334719-95-7
Price and Availability of CAS No. : 1334719-95-7
Size Price Stock
1mg $132 In-stock
5mg $396 In-stock
10mg $600 In-stock
50mg $1800 In-stock
100mg $2520 In-stock
200 mg Get quote
500 mg Get quote
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-101040
M.Wt: 557.01
Formula: C29H28ClF3N4O2
Purity: >98 %
Solubility: DMSO : 20 mg/mL (35.91 mM; Need ultrasonic)
Introduction of 1334719-95-7 :

Q203 (IAP6) is a midazopyridine amide compound. Q203 is active against Mycobacterium tuberculosis H37Rv with an MIC50 of 2.7 nM in culture broth medium. IC50 & Target: MIC50: 2.7 nM (Mycobacterium tuberculosis H37Rv)[1] In Vitro: Imidazopyridine amide (IPA) compounds block Mycobacterium tuberculosis growth by targeting the respiratory cytochrome bc1 complex. The optimized IPA compound Q203 inhibits the growth of MDR and XDR Mycobacterium tuberculosis clinical isolates in culture broth medium in the low nanomolar range. Q203 is active against the reference strain Mycobacterium tuberculosis H37Rv with MIC50s of 2.7 nM in culture broth medium and 0.28 nM inside macrophages[1]. In Vivo: Q203 is efficacious in a mouse model of tuberculosis at a dose less than 1 mg per kg body weight. Q203 displays pharmacokinetic and safety profiles compatible with once-daily dosing. Q203 has a bioavailability of 90% and a terminal half-life of 23.4 h. The volume of distribution is moderate (5.27 l per kg body weight), and the systemic clearance is low (4.03 mL/min per kg). After 4 weeks of treatment, reductions of 90%, 99% and 99.9% in M. tuberculosis H37Rv bacterial load is observed in the groups treated with Q203 at 0.4, 2 and 10 mg per kg body weight, respectively[1].

Your information is safe with us.