SKF-96365 (hydrochloride)

CAS No. : 130495-35-1

Price and Availability of CAS No. : 130495-35-1
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5mg $60 In-stock
10mg $100 In-stock
50mg $390 In-stock
100mg $650 In-stock
200mg $850 In-stock
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Cat. No. : HY-100001
M.Wt: 402.91
Formula: C22H27ClN2O3
Purity: >98 %
Solubility: DMSO : 100 mg/mL (248.19 mM; Need ultrasonic)
Introduction of 130495-35-1 :

SKF-96365 hydrochloride is a non-selective TRP Channel blocker. IC50 & Target: TRP Channel[1] In Vitro: SKF-96365 exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. SKF-96365 inhibits hERG current in a concentration-dependent manner[1]. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibits the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade. Overexpression of CaMKIIγ or AKT abolishes the effects of SKF-96365 on cancer cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects[2]. In Vivo: SKF-96365 inhibits CRC cell growth in vivo. SKF-96365 treatment results in a decrease of p-CaMKII and p-AKT as well as an increase in LC3-II, cleaved PARP, caspase-3, and caspase-9 in mice[2].

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