Size | Price | Stock |
---|---|---|
5mg | $84 | In-stock |
10mg | $132 | In-stock |
25mg | $228 | In-stock |
50mg | $348 | In-stock |
100mg | $552 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-101462 |
M.Wt: | 339.39 |
Formula: | C22H17N3O |
Purity: | >98 % |
Solubility: | DMSO : ≥ 37 mg/mL (109.02 mM) |
RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM. IC50 & Target: IC50: 27.4 μM (hRAD51)[1] In Vitro: RAD51 Inhibitor B02 specifically inhibits human RAD51 (IC50=27.4 μM), but not its E. coli homologue RecA (IC50>250 μM)[1]. The combination of B02 with cisplatin has the strongest killing effect on the human breast cancer cells MDA-MB-231[2]. In Vivo: B02 significantly enhances the therapeutic effect of cisplatin on tumor cells in vivo. B02 is tolerated by mice at doses up to 50 mg/kg without obvious body weight loss. No inhibition of tumor growth is observed on mice solely treated by B02. Mice treated with 4 mg/kg cisplatin, however, shows a 33% inhibition of tumor growth. Finally, mice treated with 50 mg/kg B02 and 4 mg/kg cisplatin shows a 66% inhibition of tumor growth[2].
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