RAD51 Inhibitor B02

CAS No. : 1290541-46-6

(Synonyms: B02)

Price and Availability of CAS No. : 1290541-46-6
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10mg $132 In-stock
25mg $228 In-stock
50mg $348 In-stock
100mg $552 In-stock
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Cat. No. : HY-101462
M.Wt: 339.39
Formula: C22H17N3O
Purity: >98 %
Solubility: DMSO : ≥ 37 mg/mL (109.02 mM)
Introduction of 1290541-46-6 :

RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM. IC50 & Target: IC50: 27.4 μM (hRAD51)[1] In Vitro: RAD51 Inhibitor B02 specifically inhibits human RAD51 (IC50=27.4 μM), but not its E. coli homologue RecA (IC50>250 μM)[1]. The combination of B02 with cisplatin has the strongest killing effect on the human breast cancer cells MDA-MB-231[2]. In Vivo: B02 significantly enhances the therapeutic effect of cisplatin on tumor cells in vivo. B02 is tolerated by mice at doses up to 50 mg/kg without obvious body weight loss. No inhibition of tumor growth is observed on mice solely treated by B02. Mice treated with 4 mg/kg cisplatin, however, shows a 33% inhibition of tumor growth. Finally, mice treated with 50 mg/kg B02 and 4 mg/kg cisplatin shows a 66% inhibition of tumor growth[2].

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