HLCL-61 (hydrochloride)
CAS No. : 1158279-20-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $75 | In-stock |
| 25mg | $130 | In-stock |
| 50mg | $195 | In-stock |
| 100mg | $300 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100025A |
| M.Wt: | 380.91 |
| Formula: | C23H25ClN2O |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (131.26 mM; Need ultrasonic); H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) |
HLCL-61 hydrochloride is a first-in-class inhibitor of protein arginine methyltransferase 5 (PRMT5).
IC50 & Target:Protein arginine methyltransferase 5[1]
In Vitro: HLCL-61 hydrochloride (1-100 μM; 24-72 hours) reduces cells growth at dose-dependent manner with IC50s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively[1].
HLCL-61 hydrochloride shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h[1].
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- HLCL-61 (hydrochloride)
- Cat. No.:
- HY-100025A
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