HLCL-61 (hydrochloride)


CAS No. : 1158279-20-9

1158279-20-9
Price and Availability of CAS No. : 1158279-20-9
Size Price Stock
10mg $108 In-stock
25mg $180 In-stock
50mg $300 In-stock
100mg $540 In-stock
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Cat. No. : HY-100025A
M.Wt: 380.91
Formula: C23H25ClN2O
Purity: >98 %
Solubility: DMSO : 50 mg/mL (131.26 mM; Need ultrasonic)
Introduction of 1158279-20-9 :

HLCL-61 hydrochloride is a first-in-class inhibitor of protein arginine methyltransferase 5 (PRMT5). IC50 & Target: Protein arginine methyltransferase 5[1] In Vitro: HLCL-61 hydrochloride (1-100 μM; 24-72 hours) reduces cells growth at dose-dependent manner with IC50s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively[1].
HLCL-61 hydrochloride shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h[1].

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