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Featured Products
HY-10005  |  Flavopiridol
HY-10008  |  SNS-032
HY-10012  |  AZD-5438
HY-10014  |  R547
HY-10032  |  PF 477736
HY-10087  |  Navitoclax
HY-10128  |  ZM-447439
HY-10161  |  Tozasertib
HY-10180  |  MLN8054
HY-10192  |  NVP-TAE 684
HY-10228  |  Motesanib
HY-10249  |  GSK-690693
HY-10355  |  AKT inhibitor VIII
HY-10358  |  MK 2206 (dihydrochloride)
HY-10992  |  AZD-7762
HY-10997  |  PCI-32765
HY-11001  |  PHA-793887
HY-11002  |  CP-466722
HY-11007  |  GNF-2
HY-11009  |  CGP60474
Products |  Featured Products
Cat.No. Product Name / Activity Added
HY-10005 Flavopiridol October 2017
Flavopiridol is a broad inhibitor of <b>CDK</b>, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with <b>IC<sub>50</sub></b> of around 40 nM.
HY-10008 SNS-032 October 2017
SNS-032 is a selective inhibitor of?<b>cyclin-dependent kinase (CDK)</b>, inhibiting <b>CDK2/7/9</b> with?<b>IC<sub>50</sub></b>s?of 48 nM/62 nM/4 nM.
HY-10012 AZD-5438 October 2017
AZD-5438 is a potent inhibitor of <b>CDK1/2/9</b> with <b>IC<sub>50</sub></b> of 16 nM/6 nM/20 nM in cell-free assays.
HY-10014 R547 October 2017
R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.
HY-10032 PF 477736 October 2017
PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.
HY-10087 Navitoclax October 2017
Navitoclax is a potent and orally bioavailable <b>Bcl-2 family protein</b> inhibitor that binds with high affinity (<b>K<sub>i</sub></b> < 1 nM) to multiple anti-apoptotic Bcl-2 family proteins including Bcl-x<sub>L</sub>, Bcl-2 and Bcl-w.
HY-10128 ZM-447439 October 2017
ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM, 130 nM respectively, > 8 fold selectivity than Aurora C, MEK1, Src.
HY-10161 Tozasertib October 2017
Tozasertib is the inhibitor of <b>Aurora-A, -B, -C kinases</b> with <b>K<sub>i</sub></b> values of 0.
HY-10180 MLN8054 October 2017
MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM; exhibits more than 40-fold selective for Aurora A than Aurora B.
HY-10192 NVP-TAE 684 October 2017
NVP-TAE 684 is a highly potent and selective <b>ALK</b> inhibitor, which blocks the growth of ALCL-derived and ALK-dependent cell lines with <b>IC<sub>50</sub></b> values between 2 and 10 nM.
HY-10228 Motesanib October 2017
Motesanib is a potent ATP-competitive inhibitor of?<b>VEGFR1/2/3</b>?with?<b>IC<sub>50</sub></b>s?of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is appr 10-fold more selective for VEGFR than PDGFR and Ret.
HY-10249 GSK-690693 October 2017
GSK-690693 is a pan-Akt inhibitor targeting?<b>Akt1/2/3</b>?with?<b>IC<sub>50</sub></b>?of 2/13/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes.
HY-10355 AKT inhibitor VIII October 2017
AKT inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit <b>Akt1</b>, <b>Akt2</b>, and <b>Akt3</b> activity with <b>IC<sub>50</sub></b>s of 58 nM, 210 nM, and 2.
HY-10358 MK 2206 (dihydrochloride) October 2017
MK 2206 is an orally active allosteric <b>Akt</b> inhibitor with <b>IC<sub>50</sub></b> of 5 nM/12 nM/65 nM for <b>Akt1/2/3</b>, respectively.
HY-10992 AZD-7762 October 2017
AZD-7762 is a potent ATP-competitive checkpoint kinase (<b>Chk</b>) inhibitor in with <b>IC<sub>50</sub></b> of 5 nM for Chk1.
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