GNE 220 (hydrochloride)
CAS No. : 2448286-21-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $650 | In-stock |
| 10mg | $1200 | In-stock |
| 25mg | $2600 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-U00428A |
| M.Wt: | 474.99 |
| Formula: | C25H27ClN8 |
| Purity: | >98 % |
| Solubility: | DMSO : 5.4 mg/mL (ultrasonic);H2O : 5 mg/mL (ultrasonic) |
GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4, with an IC50 of 7 nM. In Vitro: GNE-220 also inhibits a few other kinases with IC50s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM+ retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1+ long focal adhesions (FAs)[1].
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