Propiomazine (hydrochloride)
CAS No. : 1240-15-9
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| Cat. No. : | HY-U00051A |
| M.Wt: | 376.94 |
| Formula: | C20H25ClN2OS |
| Purity: | >98 % |
| Solubility: |
Propiomazine hydrochloride is an orally active antihistamine agent. Propiomazine hydrochloride is a potent prolactin (PRL) release stimulant, whose effect depends on the antagonism of the dopaminergic system and can inhibit the secretion of luteinizing hormone (LH). Propiomazine hydrochloride is mainly used for anesthesia assistance, mental disorders and anxiety-induced sedation, and can also be used in research related to insomnia[1][2][3][4].
In Vivo:Propiomazine (0.2 mg/kg, nasal administration, rats) hydrochloride is quickly absorbed, followed by rapid reduction of the plasma concentrations[3].
Propiomazine (25 mg/kg, i.p., at 0 and 3 h after challenge) hydrochloride protects rats against CCl4-induced hepatic injury[4].
Propiomazine (0.31-20 mg/kg, i.v.) hydrochloride increases plasma prolactin concentrations in rats[5].
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