Sarilumab
CAS No. : 1189541-98-7
(Synonyms: Anti-Human IL6Rα, Human Antibody)
| Size | Price | Stock |
|---|---|---|
| 1mg | $235 | In-stock |
| 5mg | $680 | In-stock |
| 10mg | $1150 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-P9916 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | H2O |
Sarilumab is a monoclonal antibody targeting IL6 that binds to IL6R and blocks the binding of IL6, thereby inhibiting the activation of the downstream STAT3 phosphorylation signaling pathway. In tumor cells with active IL6/STAT3 signaling pathways, Sarilumab induces Apoptosis and inhibits cell growth. Sarilumab is applicable to research related to prostate cancer, lung cancer and rheumatoid arthritis[1][2].
IC50 & Target:IL-6Ra/CD126
In Vitro:Sarilumab blocks basal STAT3 phosphorylation in DU145, Calu3 and A549 human tumor cell lines with autocrine IL6/STAT3 signaling pathway in vitro, and exerts inhibitory effects on cell lines exhibiting autocrine IL6/STAT3 signaling[1].
Sarilumab enhances tumor cell apoptosis[1].
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