Daratumumab
CAS No. : 945721-28-8
(Synonyms: Anti-Human CD38, Human Antibody; HuMax-CD38; JNJ-54767414)
| Size | Price | Stock |
|---|---|---|
| 1mg | $180 | In-stock |
| 5mg | $620 | In-stock |
| 10mg | $990 | In-stock |
| 25mg | $1850 | In-stock |
| 50mg | $2950 | In-stock |
| 100mg | $4750 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-P9915 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | H2O |
Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition[1][2]. In Vitro: Daratumumab (Anti-Human CD38) induces potent Ab-dependent cellular cytotoxicity in CD38-expressing lymphoma- and MM-derived cell lines[2]. In Vivo: Daratumumab (i.p.; 0.5 mg/kg; 14 d after challenge with Daudi-luc cells) inhibits outgrowth of CD38-expressing tumor cells in mouse xenograft tumor models[2].
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