PKG Substrate
CAS No. : 81187-14-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $125 | In-stock |
| 10mg | $185 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-P1561 |
| M.Wt: | 902.01 |
| Formula: | C35H67N17O11 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG). IC50 & Target:PKG[1] In Vitro: Incorporation of [33P]ATP into the synthetic peptide PKG substrate RKRSRAE is measured. N6-benzyl-ATP inhibits kinase activity of PKG Iα gatekeeper mutants but not WT. The serotonin transporter (SERT) is responsible for reuptake of serotonin (5-hydroxytryptamine) after its exocytotic release from neurons. SERT is regulated by several processes, including a cyclic GMP signaling pathway involving nitric oxide synthase, guanylyl cyclase, and PKG[1].
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