Substance P(1-7) (TFA)
CAS No. : 2828433-22-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $350 | In-stock |
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| Cat. No. : | HY-P1485A |
| M.Wt: | 1014.06 |
| Formula: | C43H66F3N13O12 |
| Purity: | >98 % |
| Solubility: | ;H2O : 50 mg/mL (ultrasonic) |
Substance P(1-7) TFA is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) TFA gives depressor and bradycardic effects when applied to the nucleus tractus solitarius[1]. In Vivo: Substance P(1-7) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P(1-7) is an endogenous modulator of SP actions[1]. Injection of low doses of Substance P(1-7) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord[2].
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