Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone (TFA)


Price and Availability of HY-P1407
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100μg $250 Get quote
200μg $400 Get quote
500μg $750 Get quote
1mg $1280 Get quote
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Cat. No. : HY-P1407
M.Wt: 1000.00
Formula: C31H49FN10O6·xC2HF3O2
Purity: >98 %
Solubility: H2O : 1 mg/mL (ultrasonic;warming)
Introduction of Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone (TFA) :

Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA is an irreversible MALT1 protein inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone TFA inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression[1][2]. In Vitro:Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone (Compound Z-VRPR-FMK) (50 μM, 24 h) TFA can effectively reduce the level of c-REL in the nucleus of HBL-1 cells and inhibit the signal transduction of NF-κB[2].
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone (50 μM, 48 h) TFA can inhibit the proliferation of ABC-DLBCL cell lines HBL-1, TMD8, OCI-Ly3 and OCI-Ly10[2].

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