R8-T198wt
CAS No. : 2305815-72-7
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| Cat. No. : | HY-P1404 |
| M.Wt: | 2820.33 |
| Formula: | C111H211N59O26S |
| Purity: | >98 % |
| Solubility: | H2O |
R8-T198wt is a cell-permeable carboxyl-terminal p27Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase[1].
In Vitro: R8-T198wt peptide (KD=323 nM) shows significant affinity for Pim-1. R8-T198wt peptide inhibits p27Kip1 phosphorylation by Pim-1 in cells[1].
R8-T198wt peptide induces G1 arrest and apoptosis in DU145 cells[1].
R8-T198wt treatment also enhances the HA-p27Kip1 expression level[1].
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