Pep2m, myristoylated
CAS No. : 1423381-07-0
(Synonyms: Myr-Pep2m)
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| Cat. No. : | HY-P1399 |
| M.Wt: | 1383.81 |
| Formula: | C63H118N18O14S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC)[1][2].
IC50 & Target: NSF/GluR2 interactions[1]
In Vitro: Pep2m, myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation[1].
Pep2m, myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis[1].
Pep2m, myristoylated blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture[1].
In Vivo: Pep2m, myristoylated (10 µg/20 µL) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test[2].
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