Have any questions? [email protected] +86-21-58998590
Structure search

T6167923


CAS No. : 2437475-16-4

2437475-16-4
Price and Availability of CAS No. : 2437475-16-4
Size Price Stock
5mg $278 In-stock
10mg $417 In-stock
25mg $738 In-stock
50mg $980 In-stock
100mg $1350 In-stock
200 mg Get quote
500 mg Get quote
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-19744
M.Wt: 458.39
Formula: C17H20BrN3O3S2
Purity: >98 %
Solubility: DMSO : 250 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 2437475-16-4 :

T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 ?μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively[1][2]. IC50 & Target:IC50: 2.7?μM (IFN-γ), 2.9 μM (IL-1β), 2.66 μM (IL-6), 2.66 μM (TNF-α)[2] In Vitro:T6167923 (0-500 μM; 20 h) inhibits the pro-inflammatory cytokine response of staphylococcal enterotoxin B (SEB) in peripheral blood mono nuclear cells[2].
T6167923 (10-500 μM; 2 h) inhibits secreted alkaline phosphatase response (SEAP) expression in HEK 293T cells[2].
T6167923 (100 μM; 16 h) binds to TIR protein and reduced the inhibitory effect on MyD88-signaling[2].
T6167923 (1-500 μM; 13 h) inhibits full-length MyD88 homodimeric formation[2]. In Vivo:T6167923 (0.17 and 1 mg; i.p. once) survives the mice from intoxication with SEB and LPS injection[2].

Your information is safe with us.