SBI-0640756
CAS No. : 1821280-29-8
(Synonyms: SBI-756)
| Size | Price | Stock |
|---|---|---|
| 2mg | $65 | In-stock |
| 5mg | $110 | In-stock |
| 10mg | $154 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $588 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19560 |
| M.Wt: | 404.82 |
| Formula: | C23H14ClFN2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 26 mg/mL |
SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex. IC50 & Target:eIF4G1[1] In Vitro: SBI-0640756 (SBI-756) is a water soluble inhibitor of eIF4G1. SBI-0640756 (SBI-756) (0-1 μM) disrupts eIF4F complex in parent and BRAFi-resistant melanoma. SBI-0640756 (SBI-756) shows inhibitory effect on human melanoma lines, and also suppresses AKT, NF-κB and AKT/mTORC1 activity[1]. In Vivo: SBI-0640756 (SBI-756) (0.5 mg/kg, i.p.) delays tumor onset and reduces tumor incidence by 50% in NrasQ61K/Ink4a-/- genetic model. SBI-0640756 (SBI-756) (1 mg/kg, 2 times per week, i.p.) in combination with BRAF inhibitor potently suppresses growth of established tumors and does not resume tumor growth in immunodeficient mice bearing A375 tumors[1].
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