MM41
CAS No. : 1429028-96-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $240 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $620 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16967 |
| M.Wt: | 831.06 |
| Formula: | C44H66N10O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic;adjust pH to 8 with HCl) |
MM41 is a quadruplex-interacting compound. MM41 binds tightly to quadruplexes encoded in the promoter sequences of the BCL-2 and k-RAS genes. MM41 reduces BCL-2 and k-RAS protein levels, increases caspase 3. MM41 has antitumor effects against pancreatic cancer[1].
In Vitro:MM41 (1 μM) stabilizes the BCL-2 promoter G-quadruplex with a ΔTₘ value of 26.4 °C, and also binds effectively to k-RAS1 and k-RAS2 promoter G-quadruplexes with ΔTₘ values of 22.5 °C and 19.8 °C respectively[1].
In Vivo:MM41 (10-15 mg/kg; i.v.; twice weekly; 12 doses) shows dose-dependent anti-tumour activity in MIA PaCa-2 pancreatic cancer xenografts[1].
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