AP-III-a4 (hydrochloride)
CAS No. : 2070014-95-6
(Synonyms: ENOblock hydrochloride)
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $470 | In-stock |
| 50mg | $750 | In-stock |
| 100mg | $1250 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15858A |
| M.Wt: | 631.18 |
| Formula: | C31H44ClFN8O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 53 mg/mL;H2O : 12.5 mg/mL (ultrasonic) |
AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue enolase inhibitor with an IC50 of 0.576 uM. AP-III-a4 hydrochloride can be used for the research of cancer and diabetic[1].
IC50 & Target: IC50: 0.576 uM (enolase)[1]
In Vitro: AP-III-a4 (ENOblock) (0-10 μM; 24 h) inhibits HCT116 cell viability in a dose-dependent manner[1].
AP-III-a4 directly binds to enolase and inhibits its activity[1].
AP-III-a4 (0-10 μM; 24 or 48 h) inhibits cancer cell migration and invasion, induces cancer cell apoptosis[1].
AP-III-a4 (10 μM; 24 h) can induce glucose uptake and inhibit phosphoenolpyruvate carboxykinase (PEPCK) expression in hepatocytes and kidney cells[1].
In Vivo: AP-III-a4 (ENOblock) (10 μM; 96 h) inhibits cancer cell metastasis and suppresses the gluconeogenesis regulator PEPCK in zebrafish[1].
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