GSK-J1 (lithium salt)
CAS No. : 2309668-29-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $45 | In-stock |
| 10mg | $70 | In-stock |
| 25mg | $115 | In-stock |
| 50mg | $205 | In-stock |
| 100mg | $340 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15648D |
| M.Wt: | 395.38 |
| Formula: | C22H22LiN5O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GSK-J1 lithium salt is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 of 60 nM towards KDM6B. IC50 & Target:IC50: 60 nM (KDM6B)[2] In Vitro: GSK-J1 is selective for H3K27 demethylases of the KDM6 subfamily and specifically binds to endogenous JMJD3. GSK-J1 inhibits TNF-α production by human primary macrophages in an H3K27-dependent manner[1]. GSK-J1 inhibits the demethylase activity of KDM5C with 8.5-fold increased potency compared with that of KDM5B at 1 mM α-ketoglutarate, with IC50 of 11 μM and 94 μM, respectively[3].
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