Taltobulin (hydrochloride)
(Synonyms: HTI-286 hydrochloride; SPA-110 hydrochloride)
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $435 | In-stock |
| 50mg | $652 | In-stock |
| 100mg | $980 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-15584B |
| M.Wt: | 510.11 |
| Formula: | C27H44ClN3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : 33.33 mg/mL (ultrasonic) |
Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis[1].
In Vitro: Taltobulin (HTI-286; 0.2-7.3 nM; 3 days) inhibits the growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines) with an average IC50 of 2.5±2.1 nM and a median value of 1.7 nM[1].
In Vivo: Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) in athymic nu/nu female mice[1].
Taltobulin (HTI-286; 3 mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu female mice with Lox melanoma xenografts and KB-3-1 epidermoid xenograft model, respectively[1].
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- Taltobulin (hydrochloride)
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