Atuveciclib S-Enantiomer
CAS No. : 2250279-81-1
(Synonyms: BAY-1143572 S-Enantiomer)
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| 10mg | $850 | In-stock |
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| Cat. No. : | HY-12871C |
| M.Wt: | 387.43 |
| Formula: | C18H18FN5O2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 113 mg/mL |
Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is a potent and selective CDK9 inhibitor, which inhibits CDK9/CycT1 with an IC50 of 16 nM. IC50 & Target:IC50: 16 nM (CDK9/CycT1)[1] In Vitro: In comparison with Atuveciclib (BAY-1143572), Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar in vitro properties, well within the limits of measurement accuracy; however, with multiple batches of Atuveciclib (BAY-1143572) S-Enantiomer there is a trend toward a slightly lower activity against CDK9 in the biochemical assay (IC50 CDK9/CycT1: 16 nM) and antiproliferative activity against HeLa cells (IC50: 1100 nM) [1]. In Vivo: Atuveciclib (BAY-1143572) S-Enantiomer exhibits blood/plasma ratios of about 1. Relative to Atuveciclib (BAY-1143572), Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar rat PK properties in vivo (CLb: 1.2 L/kg per hour, Vss: 1.2 L/kg, t1/2: 0.6 h, F: 53 %)[1].
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