Aminopyridine 2
CAS No. : 2411643-58-6
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| Cat. No. : | HY-126017 |
| M.Wt: | 321.18 |
| Formula: | C13H13BrN4O |
| Purity: | >98 % |
| Solubility: |
Aminopyridine 2 is an irreversible, selective, and orally active myeloperoxidase (MPO) inhibitor, with an IC50 of 0.16 μM and a Ki of 24 μM against human MPO. Aminopyridine 2 is applicable to research on chronic inflammatory diseases[1].
In Vitro:Aminopyridine 2 (2 h) inhibits the activity of human MPO in plasma, with an apparent IC50 of 1.9 μM[1].
In Vivo:Aminopyridine 2 (2.5-100 mg/kg; p.o.; single administration) dose-dependently inhibits MPO activity in a mouse peritonitis model[1].
Aminopyridine 2 (~50-200 mg/kg; mixed with diet for 14 days) dose-dependently inhibits MPO activity in a mouse peritonitis model[1].
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