PV-1019
CAS No. : 1093793-05-5
(Synonyms: NSC 744039)
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $520 | In-stock |
| 100mg | $850 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-125203 |
| M.Wt: | 379.37 |
| Formula: | C18H17N7O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 40 mg/mL (ultrasonic;adjust pH to 3 with 1 M HCL) |
PV-1019 (NSC 744039) is a potent, selective Chk2 inhibitor with an IC50 value of 24 nM. PV-1019 inhibits the Topotecan (HY-13768)-induced Chk2 autophosphorylation. PV-1019 inhibits IR-induced apoptosis[1].
In Vitro: PV-1019 (NSC 744039; 0.1-100 μM; 48 h) has antiproliferative effect in human tumor cells[1].
PV-1019 inhibits Chk2 autophosphorylation and histone H1 phosphorylation with an IC50 value of 138 nM[1].
PV-1019 (1-50 μM; 1 h; OVCAR-5 cells) inhibits the Topotecan-induced Chk2 autophosphorylation with an IC50 value of 2.8 μM[1].
PV-1019 (1 μM; 16 h) abrogates IR-induced apoptosis in mouse thymocytes[1].
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