BRD5631
CAS No. : 2446154-91-0
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| Cat. No. : | HY-125197 |
| M.Wt: | 501.62 |
| Formula: | C30H35N3O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production[1].
IC50 & Target: Autophagy[1]
In Vitro: BRD5631 (10 μM, 48 hours) leads to increased levels of LC3-II in HeLa cells. BRD5631 stimulates formation of new autophagosomes, which is consistent with its ability to increase numbers of autolysosomes in the mCherry-GFP-LC3 assay[1].
BRD5631 does not enhance autophagy by directly inhibiting mTOR or the mTOR signaling pathway. BRD5631 suppressed IL-1β secretion in an autophagy-dependent manner[1].
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