ML353
CAS No. : 2990506-75-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $220 | In-stock |
| 10mg | $350 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-124984 |
| M.Wt: | 306.33 |
| Formula: | C19H15FN2O |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
ML353 is a selective ligand of mGlu5 silent allosteric modulator (SAM) with an Ki value of 18.2 nM. ML353 improves the affinity of common allosteric sites, 20-fold higher than the previous mGlu5 SAM tool compound 5mpep. ML353 has potential applications in solving the intrinsic activity of SAM in vivo or as a agent blocker[1]. ML353 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
In Vitro: ML353 is a fully soluble compound with a solubility of 16.9 µM or 6.0 µg/mL in PBS (PH=7.4)[1].
ML353 has excellent stability in PBS buffer[1].
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