PEAQX (tetrasodium hydrate)
(Synonyms: NVP-AAM077 (tetrasodium hydrate))
| Size | Price | Stock |
|---|---|---|
| 5mg | $144 | In-stock |
| 10mg | $240 | In-stock |
| 50mg | $768 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-12294A |
| M.Wt: | 560.15 |
| Formula: | C17H15BrN3Na4O6P |
| Purity: | >98 % |
| Solubility: | H2O : 25.5 mg/mL (ultrasonic;warming) |
PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) is a tetrasodium hydrate of PEAQX (HY-12294). PEAQX tetrasodium hydrate is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures[1][2].
IC50 & Target:IC50: 270 nM, 29.6 μM (hNMDAR 1A/2A, hNMDAR 1A/2B)[1].
In Vitro:PEAQX tetrasodium hydrate (3 μM) can induce cell apoptosis and promote caspase-3 activation in cortical striatal slice cultures[2].
In Vivo:PEAQX tetrasodium hydrate (10-40 mg/kg; s.c.) can increase caspase-3 activity and enhance motor activity in the frontal cortex and striatum of rats in a dose-dependent manner[2].
PEAQX tetrasodium hydrate (10 mg/kg; once daily; i.p.) can block the CaMKIV-TORC1-CREB pathway signal induced by sigma-1 receptor (σ 1r) agonists in mice with cerebral ischemia and improve learning and memory impairments[3].
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- PEAQX (tetrasodium hydrate)
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