ZT-12-037-01
CAS No. : 2328073-61-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $88 | In-stock |
| 10mg | $154 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $750 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-122866 |
| M.Wt: | 385.50 |
| Formula: | C21H31N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;adjust pH to 2 with 1M HCl);1M HCl : 100 mg/mL (ultrasonic) |
ZT-12-037-01 is a STK19-targeted inhibitor, has a high-affinity interaction with STK19 protein and inhibits oncogenic NRAS-driven melanocyte malignant transformation. ZT-12-037-01 is an ATP-competitive inhibitor, inhibiting phosphorylation of NRAS (major isoform of Ras family) with an IC50 of 24 nM[1]. In Vitro: ZT-12-037-01 (3 μM; 14 days) significantly inhibits mutant NRAS-STK19-driven melanocyte colony formation and proliferation[1]. ZT-12-037-01 (0-3 μM) has an inhibitory effects of ZT-12-037-01 on STK19WT and STK19D89N-activated NRAS phosphorylation in HPMs[1]. In Vivo: ZT-12-037-01 (intraperitoneally injection; 25-50 mg/kg; once daily; 21 days) inhibits growth of SK-MEL-2 xenograft melanoma and the sections of tumors indicates induction of apoptosis by increasing cleaved caspase-3[1].
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