RAS inhibitor Abd-7


CAS No. : 2351843-48-4

2351843-48-4
Price and Availability of CAS No. : 2351843-48-4
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5mg $350 In-stock
10mg $550 In-stock
25mg $950 In-stock
50mg $1450 In-stock
100mg $2250 In-stock
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Cat. No. : HY-122862
M.Wt: 391.46
Formula: C23H25N3O3
Purity: >98 %
Solubility: DMSO : 125 mg/mL (ultrasonic)
Introduction of 2351843-48-4 :

RAS inhibitor Abd-7, a potent RAS-binding compound (Kd=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V[1]. In Vitro: RAS inhibitor Abd-7 (0-20 μM; 24-48 hours) is a cell-potent inhibitor affecting the viability of cancer cell lines in a single digit to low micromolar range[1].

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