SKLB-C05
CAS No. : 2300981-68-2
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| Cat. No. : | HY-122860 |
| M.Wt: | 394.89 |
| Formula: | C23H23ClN2O2 |
| Purity: | >98 % |
| Solubility: |
SKLB-C05 is a novel selective, orally active TOPK inhibitor, with an IC50 of 0.5 nM. SKLB-C05 selectively inhibit TOPK kinase. SKLB-C05 induces Apoptosis, downregulates c-Myc, γ-H2AX, activates p53, blocks FAK/Src medicated migration-related signaling. SKLB-C05 disturbs cell mitosis. SKLB-C05 shows anticancer activity only against TOPK-positive colorectal cancer[1]. IC50 & Target:IC50: 0.5 nM[1]
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