PROTAC FAK degrader 1
CAS No. : 2301916-69-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $550 | In-stock |
| 5mg | $980 | In-stock |
| 10mg | $1500 | In-stock |
| 25mg | $2550 | In-stock |
| 50mg | $3570 | In-stock |
| 100mg | $4998 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-119932 |
| M.Wt: | 996.13 |
| Formula: | C47H56F3N9O8S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
PROTAC FAK degrader 1 (Compound PROTAC-3) is a selective and effective degrader of Fak PROTAC with a DC50 of 3.0 nM. PROTAC FAK degrader 1 reduces the ability of cancer cells to migrate and invade. PROTAC FAK degrader 1 can be used in the study of tumor. (Pink: Fak ligand (HY-44146); Black: Linker (HY-44141); Blue: VHL ligand 1 (HY-125845))[1].
IC50 & Target:IC50: 6.5 nM (Focal adhesion kinase)
DC50: 3.0 nM (Focal adhesion kinase) in PC3 cells[1]
In Vitro:PROTAC FAK degrader 1 (0.5 nM-10 μM; 24 h) induces high-efficiency Fak degradation in PC3 cells in a dose-dependent manner, and significantly inhibits the phosphorylation levels of paxillin and Akt downstream of Fak[1].
PROTAC FAK degrader 1 (50-250 nM; 24 h) reduces the migration and invasion ability of MDA-MB-231 cells[1].
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